POS0964 RELATIONSHIP BETWEEN PM2.5 PARTICLE FROM HOUSEHOLD AIR POLLUTION AND INFLAMMATORY AND EPIGENETIC MARKERS IN RHEUMATIC PATIENTS FROM AN INDIGENOUS COMMUNITY IN CHIAPAS: BASELINE STUDY

Background Chronic exposure to household air pollution (HAP) from cooking by biomass leads noncommunicable diseases as chronic obstructive pulmonary disease or lung cancer (1), but it is less well known if could promote epigenetic proteomic changes leading autoimmune susceptibility. HAP remains a serious health problem for poor and marginalized indigenous communities. Recent studies have shown high prevalence of rheumatic in Latino American people (2), unknown the PM2.5 particles, be risk factor pathogenesis diseases. Objectives To evaluate relationship between levels derived inflammatory markers patients an community Chiapas, México. Methods Cross-sectional study nested cohort with Tzotzil Chiapas (Southern Mexico). Following COPCORD methodology employing instrument adapted translated into local language, pain were identified adult inhabitants community. Rheumatic diagnosis was made certified rheumatologist. Baseline blood samples collected controls without disease. particle (µg/m 3 ) measured house indoor continuously 37 hours mean accumulated calculated. Blood cytokines IL-6, IL-8 MCP-1 (H3K18ac 5-methylcitosine%) determined ELISA. Comparisons groups analyzed using Mann-Whitney U tests. Spearman correlation testing employed correlate baseline levels. Statistical significance set at 0.05%. Results The up 123 adults who live 53 houses, average age 38.3±16.2 years, where 61.2% are women 43% only speak language. Of total inhabitants, 69 14 different (11.4%) identified. Additionally, 25 biological volunteers When comparing these two groups, no significant differences found. inside houses 114.5±140.1 µg/m (8.23-462.9), while control measurements outside 9.1±5.5 (4-14.9). However, when homes controls, found (40.99 vs. 65.19 ). Likewise, observed markers, either evaluating group whole. It necessary complete citrullination sputum samples, perform deeper analysis time particle. Conclusion We suggesting that more complex than expected on health. References [1]Chen KC. et al. 2022. Indoor Air Pollution Increases Risk Lung Cancer. Int J Environ Res Public Health 19. [2]Pelaez-Ballestas, I. 2018. Epidemiology socioeconomic impact people: invisible syndemic public problem. Ann Rheum Dis. 77: 1397-1404. Acknowledgements This work supported grant CONACYT CF-2019 (#2000052). Disclosure Interests None Declared.